Virus Removal

The goal of virus removal is the reduction of viral particles in number by partitioning.

Complete viral particles are functional and infective. There are several methodologies widely used for the removal of such viruses: separation of virus from product might be achieved by adsorption of the protein product to a chromatographic matrix, while leaving the virus in the flowthrough or vice-versa.

More About Viral Clearance Viral Clearance Virus Inactivation Validation

Mechanical removal of viral particles by means of filtration, either depth filtration (20 - 40 nm pore size) in a dead-end mode or ultrafiltration (cut off <= 300 kD) in a tangential-flow mode.